In the study titled "Lysophagy protects against propagation of α-synuclein aggregation through ruptured lysosomal vesicles," published in Proceedings of the National Academy of Sciences ...

Cargo proteins that are destined for lysosomal degradation are first incorporated into intraluminal vesicles (ILVs), which form by the invagination of endosomes; this process turns endosomes into ...

Interest in lysosomal storage diseases (LSDs) has increased significantly, because several new therapeutics received FDA approval in 2003. Though long overlooked by most major pharmaceutical ...

This information is of particular importance to patients with Danon’s disease, who have mutations in a lysosomal protein that causes cardiomyopathy. We discovered that fibroblasts and cardiac myocytes ...

Recent findings suggest that tau proteins interact with extracellular vesicles (EVs), small membrane ... were enclosed within EVs enriched in endo-lysosomal proteins," wrote Fowler, Behr and ...