总而言之，这项Nature研究不仅为铁死亡领域贡献了关键性的发现，更提供了一个极具前景的治疗概念：靶向溶酶体铁，有望成为清除耐药性持续癌细胞、抑制 肿瘤转移 的新利器。细胞内的“铁锅”不再只是废物处理厂，它可能是未来癌症治疗的“终结战场”。

The duplication and division of cells is critical to keeping all multicellular organisms alive. But the opposite process is ...

The duplication and division of cells is critical to keeping all multicellular organisms alive. But the opposite process is ...

Ferroptosis, a form of programmed cell death mediated by iron, has been a focus for its potential in cancer therapies. Now, ...

New research has found that lipid peroxidation of lysosomes plays a critical role in the execution of ferroptosis.

A new class of molecules capable of killing the cancer cells that are refractory to standard treatments and responsible for recurrence has just been developed. This crucial advance in the fight ...

"Interestingly, in cancer cells that are less susceptible to ferroptosis, lipid peroxidation occurred in the lysosomes, but this did not lead to lysosomal membrane damage," continues Yamada.

SystImmune, Inc. (SystImmune), a clinical-stage biotechnology company, today announced that one abstract on izalontamab ...

Scientists have uncovered more than 20 genes whose mutations cause familial forms of Parkinson's disease. One of these genes is known as VPS13C, and mutations in this gene may contribute to the ...