Lysosomes are membrane-bound organelles in cells that act as recycling centers—breaking down waste materials, damaged ...

该篇题为"The autophagy protein ATG-9 regulates lysosome function and integrity"的文章于2025年4月9日发表在《Journal of Cell Biology》上 近日，中国科学院生物物理研究所张宏院士团队在自噬研究领域取得重要进展，首次揭示了自噬关键蛋白ATG-9通过调控磷脂翻转酶活性，促进受损溶 ...

2025年4月2日，张宏研究团队在《Autophagy》杂志发表题为"T16G12.6/IMPORTIN 13-mediated cytoplasm-to-nucleus transport of the THAP transcription factor LIN-15B controls autophagy and lysosome function in C.

Scientists have uncovered more than 20 genes whose mutations cause familial forms of Parkinson's disease. One of these genes ...

Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, report in Nature Communications on how the ...

Kanazawa University, report in Nature Communications how the targeted suppression of lysosome function may lead to brain cancer therapy.

A new set of genes that contribute to Parkinson’s disease risk has been identified.

Because lysosome dysfunction is also a prominent ... STING mediates lysosomal quality control and recovery through its proton channel function and TFEB activation in lysosomal storage disorders ...

Evidence suggests that in Parkinson’s disease, a breakdown in lysosomal function allows lipids to build up within cells. Variants of the GBA1 gene, the strongest genetic risk factor for sporadic PD, ...