Innovative delivery techniques, including high-tech nanoparticles and electroporationdevices, may convey more gene therapies ...

The ER, Golgi apparatus, and lysosomes are all members of a network of membranes, but they are not continuous with one another. Therefore, the membrane lipids and proteins that are synthesized in ...

Scientists have discovered how iron in lysosomes can induce ferroptosis, offering a new route to target treatment-resistant cancer cells and stop metastasis. Ferroptosis has been gathering an ...

By combining multi-hydroxyl fullerene (MF) nanoparticles with mTOR inhibitors, this approach triggers the domino-like collapse of lysosomes ("cellular recycling centers"), mitochondria ("power ...

Lysosomes are membrane-bound organelles in cells that act as recycling centers—breaking down waste materials, damaged organelles, and unwanted molecules using powerful digestive enzymes.

Fats and other cellular materials reach the lysosome through three main pathways: endocytosis, phagocytosis, and autophagy. In endocytosis, the cell takes in materials from outside by wrapping ...

Plastic nanoparticles (green), visible under a microscope, co-mingling with protein aggregates(red) in neuronal lysosomes (blue). Typically, concentrations of the protein aggregates are so small ...