Damaged lysosomes are repaired by a lipid-based signaling pathway dubbed PITT that could be targeted to treat neurodegenerative disease, its discoverers say. Holly Barker is a freelance journalist ...

We wanted to determine what happens to the cell when the lysosomes are not functioning well or are overwhelmed, and if there was another pathway to temporarily deal with the damaged mitochondria. This ...

The hypothesis is that intraneuronal Tau accumulation acts as a lysosomal stress signal to activate TFEB and V-ATPase expression. Further, effective TFEB/V-ATPase signaling is critical for lysosomal ...

Fats and other cellular materials reach the lysosome through three main pathways: endocytosis, phagocytosis, and autophagy. In endocytosis, the cell takes in materials from outside by wrapping ...

distinctive membrane proteins such as the lysosome-associated membrane proteins and similar maturation pathways in the endolysosomal system), LROs differ in their internal protein constituents ...

(3) A portion of mitochondria budding off as mitochondria-derived vesicles and fuse with lysosomes for degradation. (4) Depolarised mitochondria undergo morphological remodelling to squeeze their ...

By monitoring lysosomal activity in mice with GAN ... effect where the protein cannot be degraded by its normal pathway," ...

It has a range of preclinical-stage projects that aim to harness lysosomes’ ability to clear toxic materials and defective cellular components. Mutations that impair cellular clearance pathways ...

The Overholtzer lab studies mechanisms of nutrient sensing and cellular responses to nutrient starvation, including the nutrient recycling pathway autophagy ... that regulate autophagy protein and ...

Zhou, Q.H., Li, H.M., and Xue, D. (2011). Elimination of Paternal mitochondria through the lysosomal degradation pathway in C. elegans. Cell Research 21, 1662-1669 ...