Damaged lysosomes are repaired by a lipid-based signaling pathway dubbed PITT that could be targeted to treat neurodegenerative disease, its discoverers say. Holly Barker is a freelance journalist ...

The hypothesis is that intraneuronal Tau accumulation acts as a lysosomal stress signal to activate TFEB and V-ATPase expression. Further, effective TFEB/V-ATPase signaling is critical for lysosomal ...