肝细胞癌（HCC）治疗面临困境，现有疗法效果有限。研究人员开展了关于 L-741626 对 HCC 作用的研究。结果发现 L-741626 能抑制 HCC 进展，还可与索拉非尼协同增效。该研究为 HCC 治疗提供了新方向。

为解决结直肠癌（CRC）转移机制不明及缺乏有效治疗靶点的问题，研究人员开展了关于长链非编码 RNA LINC02167 在 CRC 转移中作用的研究。结果发现 LINC02167 通过 m 5 C 修饰稳定 KSR1 mRNA，激活 ERK/MAPK 通路促进转移。这为转移性 CRC 治疗提供了新靶点。

The MAPK pathway, initiated by RTKs like EGFR and HER2 ... including PI3K/Akt/mTOR, RAS/RAF/MEK/ERK, HER2, Wnt/β-catenin, Notch, NF-κB, and the DNA damage response (DDR). These pathways help ...

To examine how changes in these pathways affect ISCs, the researchers treated intestinal organoids with IFN-γ and iMEK (an inhibitor of MEK/ERK MAPK signaling). Notably, iMEK induced a quiescent ...

Aberrant activation of the Ras/Raf/MAPK/ERK kinase/extracellular signal-regulated kinase cascade and the VEGF pathway are commonly observed in breast cancer cells leading to malignant cell ...