Furthermore, a reduction in Mdm2 mobility and concomitant loss of SUMO1 staining could possibly be explained by caspase-dependent cleavage, rather than demodification, of Mdm2.

However, loss of p53 tumour-suppressor activity can also occur through amplification of MDM2. As MDM2 is a negative regulator of p53, this promotes p53 degradation and inhibits p53 tumour ...