One of the factors that determine the success of the tetramer production is the binding affinity of the peptide for the MHC class I molecule. Unfortunately, we cannot accurately predict the binding ...

All expression plasmids containing MHC alleles will be retained at our facility and will be used for future production and distribution of tetramer reagents. Requestors incur the cost of peptide that ...

The yield from a tetramer preparation is variable, but typically the product is sufficient for hundreds of stainings, often thousands of stainings. The stability of MHC class I tetramers is variable ...

Oncolytic adenovirus was engineered for the forced ectopic delivery of peptide-MHC ligand of T cell receptors (TCRs) to ...

Recently developed major histocompatibility complex (MHC) multimer technologies allow visualization and isolation of antigen-specific T cells. However, functional analysis and in vivo transfer of ...

How many naive T cells that are specific for any one peptide–MHC complex exist in an individual? How does that number influence the immune response? Answers to these questions have remained ...

“Currently, we’ve been simply guessing which HIV peptides might match with the MHC molecule and are testing them one by one. But with millions of possibilities, were stuck in that infinite scroll,” ...

Peptides that bind major histocompatibility complex (MHC) class I molecules act as chemosensory signals in a region of the brain thought to be important in chemosensory communication, according to a ...