MYC 在 ecDNA 上的扩增为肿瘤细胞提供了快速适应环境的机制，然而，高负荷的 ecDNA 会给癌细胞带来适应性成本，只有在特定的微环境条件下，ecDNA 才能为癌细胞提供生存优势。此外，研究还发现 p53 失活可能是 PDAC 中 ecDNA 形成的先决条件，但其具体形成机制仍需 ...

撰文 | 冉茂双 责编 | 周叶斌MYCN的异常表达与多种人类癌症的肿瘤发生密切相关，其中MYCN扩增是高危神经母细胞瘤 (NB) 的主要遗传驱动因素，也是临床上最强的独立不良预后因素。MYCN基因编码致癌转录因子N-Myc在正常神经前体细胞中泛素化 ...

Heat-shock protein 90 (Hsp90) inhibitor downregulates c-Myc expression and upregulates the expression of tumor repressor proteins such as p53 and pRB, inhibiting the G1/S transition and causing G2 ...

Researchers sought to evaluate differences in ctDNA profiles, use of targeted treatments, and overall survival between Black and White patients with metastatic breast cancer.

The MYC family of proteins ... studied oncogenes and is an excellent target for cancer therapy, based on its p53-dependent and p53-independent oncogenic activities in various cancers.