恶性肿瘤的免疫治疗因T细胞浸润不足在实体瘤中受限，而巨噬细胞作为肿瘤微环境的核心组分，其功能调控成为关键突破口。

Researchers in South Korea have proposed a novel cancer immunotherapy approach that could complement existing CAR-T (Chimeric ...

This study provides proof-of-principle data for the use of trained immunity to modulate macrophage interactions with tumours. The study makes a valuable contribution to the field of trained immunity.

"The fact that viral RNA alone seems to be able to trigger memory in macrophages lays the foundation of this memory being antigen independent," Lercher says. "They're recognizing a pattern that is ...

Iron-dependent ferroptosis, a non-apoptotic cell death mechanism, is gaining attention for its role in immune suppression. Ferroptosis, driven by excessive lipid peroxides and iron-dependent reactive ...