GPIIb/IIIa and other platelet-related antigens. In addition to direct pathogenic effects of antibodies on megakaryocytes, there is evidence that cell-mediated cytotoxicity, complement activation ...

Colour-enhanced image of platelets (green) and red blood cells. Platelets are necessary for the blood clotting process and are generated from large cells called megakaryocytes. Neither platelets nor ...

Megakaryocytes (MKs), known for their role in platelet production, have emerged as critical players in immune responses, showcasing versatility in both physiological and pathological contexts.

“The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors,” Nature, 544:105-09, 2017. Lung intrigue Platelets form when megakaryocytes release bits of their specialized ...

Future Microbiol. 2013;8(11):1431-1451. Bacterial contact with the platelets is a key event for the pathogenesis of sepsis, as deduced from the correlation between sepsis outcome and decreased ...

This summer, an article he co-authored was published in Platelets, a peer-reviewed medical journal covering all aspects of platelet-related research. The article, “In vitro culture of murine ...

Platelets are made by megakaryocytes, a giant cell located in bones and lungs, making them hard to study. Each megakaryocyte can generate up to 5,000 platelets. In this project, we propose to study ...

My research focuses on one particular cell lineage, the megakaryocytes. These large, polyploid cells mature and then break up into little pieces called thrombocytes or platelets. Before this occurs, ...