CURE spoke with John Crispino, the director of the division of experimental hematology at St. Jude Children’s Research Hospital.

Megakaryocytes (MKs), known for their role in platelet production, have emerged as critical players in immune responses, showcasing versatility in both physiological and pathological contexts.

Lung intrigue Platelets form when megakaryocytes release bits of their specialized cytoplasm, a process long thought to occur primarily in the bone marrow. Mark Looney, a pulmonologist at the ...

GPIIb/IIIa and other platelet-related antigens. In addition to direct pathogenic effects of antibodies on megakaryocytes, there is evidence that cell-mediated cytotoxicity, complement activation ...

Future Microbiol. 2013;8(11):1431-1451. Platelet GPIIIa, and even the same epitope within this surface protein, are also targets of autoantibodies, which are generated in HIV-infected patients.

My research focuses on one particular cell lineage, the megakaryocytes. These large, polyploid cells mature and then break up into little pieces called thrombocytes or platelets. Before this occurs, ...

a peer-reviewed medical journal covering all aspects of platelet-related research. The article, “In vitro culture of murine megakaryocytes from fetal liver-derived hematopoietic stem cells,” outlines ...

Colour-enhanced image of platelets (green) and red blood cells. Platelets are necessary for the blood clotting process and are generated from large cells called megakaryocytes. Neither platelets nor ...

Future Microbiol. 2013;8(11):1431-1451. Bacterial contact with the platelets is a key event for the pathogenesis of sepsis, as deduced from the correlation between sepsis outcome and decreased ...