GPIIb/IIIa and other platelet-related antigens. In addition to direct pathogenic effects of antibodies on megakaryocytes, there is evidence that cell-mediated cytotoxicity, complement activation ...

CURE spoke with John Crispino, the director of the division of experimental hematology at St. Jude Children’s Research Hospital.

Colour-enhanced image of platelets (green) and red blood cells. Platelets are necessary for the blood clotting process and are generated from large cells called megakaryocytes. Neither platelets nor ...

Megakaryocytes (MKs), known for their role in platelet production, have emerged as critical players in immune responses, showcasing versatility in both physiological and pathological contexts.

“The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors,” Nature, 544:105-09, 2017. Lung intrigue Platelets form when megakaryocytes release bits of their specialized ...

This summer, an article he co-authored was published in Platelets, a peer-reviewed medical journal covering all aspects of platelet-related research. The article, “In vitro culture of murine ...

My research focuses on one particular cell lineage, the megakaryocytes. These large, polyploid cells mature and then break up into little pieces called thrombocytes or platelets. Before this occurs, ...