▎药明康德内容团队编辑 作为一个高度复杂的器官，大脑每天会处理海量信息，这也让大脑累积了大量的代谢废物。如果这些“垃圾”不及时清除，将会引发炎症反应和神经损伤，对注意力、认知、记忆等大脑功能造成破坏。早在2012年，神经科学家Maiken ...

As we get older, the essential cleaning processes that our brains need to keep functioning start to break down and fail.

本项研究 发现，在老年小鼠中恢复脑膜淋巴管功能可逆转与年龄相关的突触和行为改变。 研究结果表明，脑膜淋巴管功能障碍通过依赖 IL-6 的机制对皮质回路产生不利影响，并确定了治疗与衰老相关的认知衰退的一个潜在靶点。

Explore the critical differences in how women's pain is processed and how tailored treatments can alleviate chronic pain.

如今，来自华盛顿大学医学院的研究人员报告说，他们找到了一种解决这个问题的方法，即靶向从大脑中排出废物的淋巴管网络。他们证实让这些淋巴管恢复青春可以提高老年小鼠的记忆力。这一发现为开发与年龄相关的认知能力下降的疗法奠定了基础，这也有助于克服传统药物难以通过血脑屏障到达大脑所面临的挑战。相关研究结果发表在 Cell 杂志上。

Microglia, the brain's immune cells, usually serve as diligent guardians. They eliminate intruders such as microbes and clear ...

Microglia, Pediatric Neurology, Autism Spectrum Disorder, Epilepsy, Neuroinflammation, Neurodevelopment Kaur, H. (2025) The ...

Microglia are brain-resident macrophages playing pivotal roles in CNS development and homeostasis. Yet, the cellular and molecular basis governing microglia maintenance ...

A comprehensive Thought Leaders Invited Review in Brain Medicine highlights the crucial role of CD2-associated protein (CD2AP ...

Notably, microglia spatially associated with amyloid plaques exhibited increased expression of TREM2 and ApoE compared to ...