本项研究 发现，在老年小鼠中恢复脑膜淋巴管功能可逆转与年龄相关的突触和行为改变。 研究结果表明，脑膜淋巴管功能障碍通过依赖 IL-6 的机制对皮质回路产生不利影响，并确定了治疗与衰老相关的认知衰退的一个潜在靶点。

Now, two independent studies have honed in on inflammatory microglia as a potential therapeutic strategy. In mice, induction of T regulatory (T reg) cells or supplementation with a metabolic ...

Microglia, the brain's immune cells, usually serve as diligent guardians. They eliminate intruders such as microbes and clear ...

Microglia are brain-resident macrophages playing pivotal roles in CNS development and homeostasis. Yet, the cellular and molecular basis governing microglia maintenance ...

如今，来自华盛顿大学医学院的研究人员报告说，他们找到了一种解决这个问题的方法，即靶向从大脑中排出废物的淋巴管网络。他们证实让这些淋巴管恢复青春可以提高老年小鼠的记忆力。这一发现为开发与年龄相关的认知能力下降的疗法奠定了基础，这也有助于克服传统药物难以通过血脑屏障到达大脑所面临的挑战。相关研究结果发表在 Cell 杂志上。

Common treatments may not be as effective for women as they are for men, mouse model reveals In a nutshell Research reveals ...

Researchers suspected that microglia could also break down amyloid plaques, but it was unclear how the cells could consume these massive aggregates, which are much bigger than they are. "We found ...

Notably, microglia spatially associated with amyloid plaques exhibited increased expression of TREM2 and ApoE compared to ...

This lack of progress has prompted many research groups to look instead at non-neuronal cells in the brain, and in particular, at immune cells known as microglia. Vital in both developing and mature ...