Up to a quarter of the regional microglial population is donor-derived by four months after transplantation. Microglial engraftment is enhanced by neuropathology, and gene-modified myeloid cells ...

A comprehensive Thought Leaders Invited Review in Brain Medicine highlights the crucial role of CD2-associated protein (CD2AP ...

However, when the brain is subjected to hyperosmotic stress—a condition characterized by elevated extracellular sodium levels, the microglial response can become exaggerated, leading to ...

Figure 1: Brain MRI scans (1.5T) of a patient with clinical, pathological and molecular diagnosis of Nasu–Hakola disease. Nasu–Hakola disease is emerging as the prototype of a primary ...

Traditional hypotheses have focused on amyloid-beta plaques and Tau pathology, but recent findings point to a significant role for microglial dysfunction and mitochondrial impairment. Given these ...