Up to a quarter of the regional microglial population is donor-derived by four months after transplantation. Microglial engraftment is enhanced by neuropathology, and gene-modified myeloid cells ...

A comprehensive Thought Leaders Invited Review in Brain Medicine highlights the crucial role of CD2-associated protein (CD2AP ...

Figure 1: Brain MRI scans (1.5T) of a patient with clinical, pathological and molecular diagnosis of Nasu–Hakola disease. Nasu–Hakola disease is emerging as the prototype of a primary ...

However, when the brain is subjected to hyperosmotic stress—a condition characterized by elevated extracellular sodium levels, the microglial response can become exaggerated, leading to ...

Traditional hypotheses have focused on amyloid-beta plaques and Tau pathology, but recent findings point to a significant role for microglial dysfunction and mitochondrial impairment. Given these ...