Mitochondria in intact cells can transiently accumulate calcium during cell stimulation. The heterogeneity of the response, the extremely high calcium concentrations reached in the mitochondrial ...

Because the mitochondria have a large capacity for calcium uptake (through the potential-driven calcium uniporter) 11,12,16, they might be neuroprotective by removing calcium from the cytoplasm 17.

Calcium transport into and out of mitochondria – the powerhouses of cells – is central to cellular energy production and cell death. To maintain the balance of calcium within these powerhouses ...