Mammalian mtDNA encodes key components of the oxidative phosphorylation (OXPHOS) machinery, which drives mitochondrial ATP ... using a high-throughput in vitro DNA synthesis assay.

Scientists found a compound that appears to counter common mutations behind POLG-related diseases, rare conditions that harm ...

Many mitochondrial diseases have been difficult to study and treat due to the inherent challenges in accessing mitochondrial DNA (mtDNA). Now, researchers have optimized mitochondrial-targeted ...

The proposed system can selectively increase or decrease the proportion of mutant to normal (or ‘wild-type,’ WT) ...

The DNA within mitochondria needs to be replicated as new mitochondria are made. Mitochondrial DNA must also be repaired after factors like oxidative stress damage it. However, around 300 ...

Despite the massive successes of immunotherapy, which utilizes the body's immune system as a tool to fight cancer, therapy resistance is still a common treatment obstacle for many patients with solid ...

Some of these conditions result from mutations in mitochondrial DNA (mtDNA), the genetic material housed in these organelles. For patients with the common m.3243A>G mutation, which can cause MELAS ...

The following is a summary of “Mitochondrial DNA copy number variation in asthma risk, severity, and exacerbations,” ...

A medical breakthrough could result in the first treatment for rare but serious diseases in which genetic defects disrupt ...