They found, surprisingly, that female mice that lacked ARC estrogen signaling had improved bone health. 2 “The bone phenotype was really phenomenal,” said Ingraham. “They were not only very dense, but ...

First, they analyzed the changes that occur in the calvarial bone of mice during aging, finding a clear decline in both bone structure and healing capacity with age. The team noticed a reduction ...

We routinely prepare and analyse human (biopsies) and mouse bone tissues for static (on decalcified samples) and dynamic histomorphometry (on undecalcified samples). We also extend our histological ...

A drop in estradiol and progesterone levels after menopause could increase cartilage aging and degeneration, leading to osteoarthritis, a study in mice suggests.

Researchers have developed a gene therapy that may provide a long-term treatment for hypophosphatasia. Unlike current ...

Supplementary Figure 2 from the new study shows results from radiographic analysis of long bones in mice treated with gene therapy for early onset hypophosphatasia. The smaller dosages in the first ...

For the last 10 years, the only effective treatment for hypophosphatasia (HPP) has been an enzyme replacement therapy that ...

We can provide expertise in generating, calibrating and validating computational models for bone samples extracted from large mammals (trabecular and cortical bone samples) as well as mouse bones (in ...