Muscarinic acetylcholine receptors (mAChRs) are a type of receptor in the brain that respond to the neurotransmitter acetylcholine. They play a crucial role in various brain functions, including ...

The pharmacotherapy of schizophrenia is currently dominated by atypical antipsychotics that primarily target dopaminergic signalling, the dysregulation of which has long been considered to have a ...

A pathway once considered fundamental in Alzheimer’s disease is being studied intensely again, and may soon result in safer, ...

Cobenfy has created a lot of excitement because it applies a new mechanism to treat schizophrenia – it targets muscarinic acetylcholine receptors, found in cell membranes. In particular ...

As per the Brain and Behavior Research Foundation, it combines two compounds called xanomeline and trospium chloride. This is ...

Our recent work (McQuail & Burk, 2006) suggests that cholinergic muscarinic receptors, particularly the muscarinic M1 receptor, are important for mediating the effects of the cortical acetylcholine on ...

Cholinergic drugs (acetylcholine and methacholine ... both events explain the increase in airway resistance. Muscarinic (M) receptors involved in the airway tone regulation are as follows ...

Muscarinic receptors are involved with neurotransmission via acetylcholine and glutamate, and are hypothesised to be dysfunctional in schizophrenia. Most drugs developed to treat schizophrenia to ...

Nxera and Neurocrine entered a collaboration and licensing agreement in 2021 to develop a portfolio of novel clinical and preclinical subtype-selective muscarinic M4, M1 and dual M1/M4 receptor ...

Homatropine is an anticholinergic that inhibits activity of the muscarinic acetylcholine receptor with less potency than atropine. Abuse potential (monitor). Life-threatening respiratory ...