Here the heart muscle must work harder to pump an adequate volume of blood ... Several projects in the lab assess the effects of individual mutations on protein function, incorporation into the ...

An individual sarcomere contains many parallel actin ... Milestone 3 (1954): Sliding filament model for muscle contraction. Muscle sliding filaments. Nature Reviews Molecular Cell Biology 9 ...

There is no effective treatment for this disease. Mutations in over nine different genes have been linked to NM, six of which encode skeletal muscle sarcomere thin filament-associated proteins. Using ...