In the second model system, we used DNA from 60 cell lines (NCI60 panel) for mutation detection (Fig. 3). The NCI60 cells are thoroughly characterized using gene expression, DNA methylation and ...

But when U.S. National Institute of Standards and Technology researchers Christina Bergonzo and Alexander Grishaev put ...

Mitochondrial diseases, arising from mutations in mitochondrial DNA (mtDNA), are a diverse group of disorders that lead to severe conditions. Expression of mtDNA is a prerequisite for ATP production ...

This DNA has suffered a mutation, either through mis-copying (when its parent cell divided), or through the damaging effects of exposure to radiation or a chemical carcinogen.

The team is optimizing the cancer genome analysis system to integrate it into CRC diagnosis and tailor treatments based on ...

Scientists have developed a new type of machine learning model that can understand and design genetic instructions. The model ...

Colorectal cancer (CRC), a type of cancer that affects the large intestine and rectum, is one of the leading causes of cancer ...

Scientists have created a mega-database revealing how half a million different DNA mutations generate errors in proteins in humans. The researchers hope that the database will be used to develop ...

A new study reveals how the Dnmt3a mutation drives blood stem cell overgrowth, contributing to clonal hematopoiesis and ...