How pharmacogenomics might help addiction treatment Naltrexone Molecule 20 years ago, scientists got hooked on a single transcription factor that responds to a number of drugs of abuse. Will their ...

Naloxone (Narcan), naltrexone (Trexan; ReVia), and Vivitrol (long-acting injectable naltrexone) changed addiction medicine into a profession with FDA-approved treatments for opioid overdose ...

A small molecule of the naltrexone, an opioid mimic, nestles neatly into a cavity — called a binding site — of a protein selected for just that purpose by UW–Madison researchers using a new ...

Daily oral and monthly extended-release injectable naltrexone were similarly effective at reducing heavy drinking days in patients with alcohol use disorder (AUD), a hospital-based randomized ...

Starting oral or injectable naltrexone at hospital discharge reduced heavy drinking in patients with alcohol use disorder. The hospital is an opportune setting for identifying and treating ...

Now, the combination of bupropion and naltrexone is being studied for possible weight-loss effects through its synergistic action on appetite signaling and the mesolimbic reward system.