Accumulation of a protein called TDP-43 is a key feature of ALS and frontotemporal dementia. In a newly published study, ...

Researchers have revealed for the first time how a key protein linked to Parkinson's mutates, leads to cell death in the ...

Huntington's disease is a rare genetic, autosomal dominant, neurodegenerative disease, caused by CAG repeat expansions in the ...

The liquid effectively stopped amyloid-β-induced neuronal cell death. The neuroprotective factor at work is thought to be Fibroblast Growth Factor 23 (FGF23), an endocrine protein. Treating ...

elegans and mammalian neuronal cultures (Fonte et al, 2011). We propose that a primary mechanism of Abeta toxicity is the formation of membrane-damaging oligomers, which is blocked by the G37L ...

This finding has implications for understanding neuronal identity in vertebrates, as many of the mechanisms discovered in this model are also present in mice, humans, and other species.

The investigators then demonstrated that the dysregulation of this metabolic pathway led to increased lipid peroxidation—a process that damages cellular membranes and may trigger neuronal death.