Organisms use enzymes to produce nonribosomal peptides, and ribosomes to produce proteins via reactions that differ in details from dehydration synthesis. Some peptides, like alpha-amanitin, are ...

Reference: Pistofidis A, Ma P, Li Z, Munro K, Houk KN, Schmeing TM. Structures and mechanism of condensation in nonribosomal peptide synthesis. Nature. 2024. doi: 10.1038/s41586-024-08417-6 This ...

The molecular machines that Pistofidis and Schmeing studied are called nonribosomal peptide synthetases, or NRPSs. They build some of the most important compounds in current health care and ...