The NOTCH family includes four receptors (NOTCH1-4) and interacts with ligands like Delta-like (DLL ... Noncanonical ...

Cancer remains a leading cause of death globally, with lung cancer being particularly lethal. Despite advancements in diagnostics and therapies, the five-year survival rates for advanced tumors have ...

Which of the two faces is shown is dependent on the cellular context and the crosstalk with other signal-transduction pathways. Notch signalling participates in the development of multicellular ...

In this long-term work, the researchers demonstrated that the NOTCH signaling pathway, conserved throughout the evolution of all multicellular organisms, plays an essential role in the ...