In this long-term work, the researchers demonstrated that the NOTCH signaling pathway, conserved throughout the evolution of all multicellular organisms, plays an essential role in the ...

Cancer remains a leading cause of death globally, with lung cancer being particularly lethal. Despite advancements in diagnostics and therapies, the five-year survival rates for advanced tumors have ...

The Gairdner Awards, which celebrate scientists who have made seminal discoveries or contributions to biomedical research, ...

Nicastrin activates the Notch pathway by cleaving the Notch receptors ... Adapted from Remark et al., 2023, Bone Research (CC BY 4.0 DEED). By looking at the transcriptional profile of the ...