Hrt genes are the best studied Notch targets in the heart; here they have crucial functions in cardiac morphogenesis by regulating chamber-specific gene expression, atrioventricular canal ...

Signalling between Notch receptors and ligands influences many differentiation processes and cell-fate decisions during embryonic and postnatal development. Stem-cell maintenance, binary cell-fate ...

The Notch gene family encodes transmembrane receptors with a dual capability to suppress or induce cell differentiation. This may have important consequences for tumorigenesis but the exact role of ...