Ten years of substantial work by Université de Montréal immunologist Nathalie Labrecque's team at the Montreal Clinical ...

The Notch gene family encodes transmembrane receptors with a dual capability to suppress or induce cell differentiation. This may have important consequences for tumorigenesis but the exact role of ...

Hrt genes are the best studied Notch targets in the heart; here they have crucial functions in cardiac morphogenesis by regulating chamber-specific gene expression, atrioventricular canal ...

Signalling between Notch receptors and ligands influences many differentiation processes and cell-fate decisions during embryonic and postnatal development. Stem-cell maintenance, binary cell-fate ...

No writing assistance was utilized in the production of this manuscript. CADASIL is caused by mutations in the NOTCH3 gene (in 19p13.1-13.2) encoding a 280 kDa transmembrane receptor. Virtually ...