Hrt genes are the best studied Notch targets in the heart; here they have crucial functions in cardiac morphogenesis by regulating chamber-specific gene expression, atrioventricular canal ...

Signalling between Notch receptors and ligands influences many differentiation processes and cell-fate decisions during embryonic and postnatal development. Stem-cell maintenance, binary cell-fate ...

The Notch gene family encodes transmembrane receptors with a dual capability to suppress or induce cell differentiation. This may have important consequences for tumorigenesis but the exact role of ...

This important study provides solid evidence that glucosylceramide synthase (GlcT), a rate-limiting enzyme for glycosphingolipid (GSL) production, plays a role in the differentiation of intestinal ...