This manuscript demonstrates that Oct4 overexpression synergizes with Notch inhibition (Rbpj knockout) to promote the conversion of adult murine Müller glia (MG) into bipolar cells. These findings are ...

The results of recent experiments implicate this signalling pathway in many stages of heart development, and provide mechanistic insight into the vital functions of Notch in the aetiology of ...

Noncanonical signaling involves interactions with other pathways without RBPJ involvement. The NOTCH pathway contributes to ...

Cancer remains a leading cause of death globally, with lung cancer being particularly lethal. Despite advancements in diagnostics and therapies, the five-year survival rates for advanced tumors have ...

Why did it take so many patients to define the MTD? Importantly, are we any closer to understanding the biology of targeting the Notch pathway? In the study of RO4929097 by Tolcher et al, 1 the ...

Ten years of substantial work by Université de Montréal immunologist Nathalie Labrecque's team at the Montreal Clinical ...