Noncanonical signaling involves interactions with other pathways without RBPJ involvement. The NOTCH pathway contributes to ...
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Understanding the roles of NOTCH signaling in cancer resistanceCancer remains a leading cause of death globally, with lung cancer being particularly lethal. Despite advancements in diagnostics and therapies, the five-year survival rates for advanced tumors have ...
Ten years of substantial work by Université de Montréal immunologist Nathalie Labrecque's team at the Montreal Clinical ...
Why did it take so many patients to define the MTD? Importantly, are we any closer to understanding the biology of targeting the Notch pathway? In the study of RO4929097 by Tolcher et al, 1 the ...
This manuscript demonstrates that Oct4 overexpression synergizes with Notch inhibition (Rbpj knockout) to promote the conversion of adult murine Müller glia (MG) into bipolar cells. These findings are ...
The data also revealed an association between age-related bone degeneration and a significant upregulation of Notch signaling genes, suggesting that this pathway becomes abnormally active in SSPC as ...
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