The Notch family of transmembrane receptors comprises four members, with roles in the regulation of cell fate and growth. Following ligand binding, a conformational change in the receptor negative ...

Scientists engineered T cells to protect instead of kill, potentially enabling targeted treatments for autoimmune disease and transplant rejection.

While platforms like chimeric antigen receptors and synthetic Notch receptors offer novel capabilities, they often lack versatility, particularly in responding to both soluble and cell-surface ...

For example, activation of a synthetic Notch (synNotch) receptor that binds one antigen can trigger the expression of a CAR targeting another antigen. 5 (4) A CAR controlled remotely via drugs and ...