In this long-term work, the researchers demonstrated that the NOTCH signaling pathway, conserved throughout the evolution of all multicellular organisms, plays an essential role in the ...

A cell signaling mechanism of fundamental importance to animal development is the Notch pathway (Figure 1). It may be safely said that Notch signaling is required, in some reasonably direct fashion, ...

The Gairdner Awards, which celebrate scientists who have made seminal discoveries or contributions to biomedical research, ...

Noncanonical signaling involves interactions with other pathways without RBPJ involvement. The NOTCH pathway contributes to resistance by regulating cell survival, apoptosis, and the tumor ...

Noncanonical signaling involves interactions with other pathways without RBPJ involvement. The NOTCH pathway contributes to resistance by regulating cell survival, apoptosis, and the tumor ...

The data also revealed an association between age-related bone degeneration and a significant upregulation of Notch signaling genes, suggesting that this pathway becomes abnormally active in SSPC as ...

Tsakonas, professor of cell biology, emeritus, in the Blavatnik Institute at Harvard Medical School, has received a ...