NOTCH signaling plays a crucial role in tumorigenesis and therapeutic resistance, with its activation linked to drug resistance in various cancers. The NOTCH family includes four receptors (NOTCH1 ...

NOTCH signaling plays a crucial role in tumorigenesis and therapeutic resistance, with its activation linked to drug resistance in various cancers. The NOTCH family includes four receptors (NOTCH1 ...

A cell signaling mechanism of fundamental importance to animal development is the Notch pathway (Figure 1). It may be safely said that Notch signaling is required, in some reasonably direct fashion, ...

In this long-term work, the researchers demonstrated that the NOTCH signaling pathway, conserved throughout the evolution of all multicellular organisms, plays an essential role in the ...

In all vertebrates that have been analysed so far, the expression of transcripts that encode the transforming growth factor-β (TGFB)-like signal NODAL is restricted to the left lateral plate ...