More information: Dave Maurice De Sousa et al, Early Notch signals from fibroblastic reticular cells program effector CD8+ T cell differentiation, Journal of Experimental Medicine (2025). DOI: 10. ...

Get Instant Summarized Text (Gist) The NOTCH signaling pathway is crucial for the differentiation of CD8 + T cells, essential for an effective immune response. This process begins early, with ...

NOTCH induces MYC, connecting two signaling programs that enhance ... of gain and loss of miR-30a in diffuse large B-cell lymphoma (DLBCL) and T-acute lymphoblastic leukemia (T-ALL) cells ...

One broad category is “inhibitory” signaling, whereby Notch prevents a cell from adopting a particular cell fate ... Ueberschär M, Wang W, Zhang C, Kondo S, Aoki T, Schedl P, Lai EC*, Wen J* and Dai Q ...

Tsakonas, professor of cell biology, emeritus, in the Blavatnik Institute at Harvard Medical School, has received a ...

This manuscript demonstrates that Oct4 overexpression synergizes with Notch inhibition (Rbpj knockout) to promote the conversion of adult murine Müller glia (MG) into bipolar cells. These findings are ...

Based on these findings, the team examined whether the Notch signaling pathway controls SSPC differentiation, making these cells more likely to become adipocytes with aging. To do so, they used ...