Involved from the start In the new study, Labrecque's team demonstrated that NOTCH signaling is involved from the very start of the CD8 + T cell differentiation period, which lasts around seven to ...

NOTCH induces MYC, connecting two signaling programs that enhance ... of gain and loss of miR-30a in diffuse large B-cell lymphoma (DLBCL) and T-acute lymphoblastic leukemia (T-ALL) cells ...

One broad category is “inhibitory” signaling, whereby Notch prevents a cell from adopting a particular cell fate ... Ueberschär M, Wang W, Zhang C, Kondo S, Aoki T, Schedl P, Lai EC*, Wen J* and Dai Q ...

Noncanonical signaling involves interactions with other pathways without RBPJ involvement. The NOTCH pathway contributes to resistance by regulating cell survival, apoptosis, and the tumor ...

T-cell acute lymphoblastic leukaemia (T-ALL) is a paediatric leukaemia associated with distinct clinical and biological characteristics. Historically linked with a poor prognosis, T-ALL represents ...

Tsakonas, professor of cell biology, emeritus, in the Blavatnik Institute at Harvard Medical School, has received a ...

Based on these findings, the team examined whether the Notch signaling pathway controls SSPC differentiation, making these cells more likely to become adipocytes with aging. To do so, they used ...

This approach optimizes T-cell receptor signaling, reduces reliance on exogenous ... improving safety while preserving CAR function. Synthetic NOTCH receptors offer tighter control over CAR ...