In the vertebrate spinal cord, opposing gradients of Sonic Hedgehog, which emanate from the floor plate and notochord, and bone morphogenetic proteins and Wnts, which originate in the roof plate ...

This is particularly important, as a working notochord in human stem cells could help further research into how birth defects affect the spine or spinal cord. The researchers note that it could ...

To create a lab-grown notochord, researchers first studied ... light on the causes of birth defects affecting the spine and spinal cord. It could also provide valuable insights into conditions ...

The notochord, a rod-shaped tissue ... this work could help to study birth defects affecting the spine and spinal cord. It could also provide insight into conditions affecting the intervertebral ...

"What's particularly exciting is that the notochord in our lab-grown structures ... into how birth defects affect the spine or spinal cord. "It could also be valuable for studying intervertebral ...