此外，还观察到胆碱酯酶活性下降和组织架构改变。通过 qRT - PCR 分析 mRNA 表达发现，与抗氧化防御相关的基因（SIRT1、Nrf2、HO - 1、NQO1）上调，同时细胞凋亡标志物半胱天冬酶 - 8（caspase - 8）和半胱天冬酶 - 3（caspase - 3）下调。该研究突出了 CoQ10、BCA 和 PHL 通过 ...

编辑推荐：针对胃癌化疗耐药难题，南昌大学第一附属医院团队揭示TMEM160通过招募E3连接酶TRIM37促进KEAP1的K48泛素化降解 ...

"Horses can make this fire burn even hotter and make the damage even less than it would be in a species like a human," said Castiglione. The changes occurred in a key gene pathway called NRF2/KEAP1.

In the current study, researchers focused on the gene KEAP1 and the KEAP1-NRF2 pathway, which regulates antioxidant responses and mitochondrial energy production. In birds, this pathway evolved to ...

In the current study, researchers focused on the gene KEAP1 and the KEAP1-NRF2 pathway, which regulates antioxidant responses and mitochondrial energy production. In birds, this pathway evolved to ...