Bile acids are transported in portal blood to the liver where bile acids are taken up by hepatocytes via the Na+-dependent taurocholate co-transporting polypeptide (NTCP) and organic anion ...

Axiomer ADAR-mediated RNA editing pipeline advancing across liver and CNS programs, with CTA filing on track for Q2 2025 for lead program AX-0810 targeting NTCP for Cholestatic diseases Strengthened ...

The large arginine side chain at position 158 in mNTCP, which inhibits deep preS1 insertion into the NTCP bile acid pocket, ...

Figure 1: Steady-state mRNA levels of genes that are regulated by Tcf1. Figure 4: Bile acid concentrations are increased in the serum, stool and urine of Tcf1 −/− mice. Figure 5: Tcf1 is a ...

As well as having a role in lipid absorption, bile acids can act as endocrine-signaling molecules. With previous studies suggesting that bile acids operate as metabolic integrators, Watanabe et al.