Three recent manuscripts have reexamined the location of H1 within the nucleosome particle and its function in the regulation of transcription. As its name suggests, the fifth histone is ...

A group including Jonathan Widom at Northwestern University and Eran Segal of the Weizman Institute used sophisticated computer modeling along with experimental approaches to uncover DNA-encoded rules ...

The cell's genetic material, DNA, is packaged into tightly wound structures called nucleosomes. The DNA (red) is wound around two sets of core histone proteins (green) to form a kind of bead on a ...

Lipopolysaccharide (LPS) induction of the gene encoding interleukin 12 p40 requires remodeling of a promoter-encompassing nucleosome and the Toll-like receptor (TLR)–mediated activation of a c ...