DNA containing a repeated nucleosome-positioning sequence was combined ... It will be essential to establish cell-free systems for chromosomal transactions such as transcriptional activation ...

Scientists at St. Jude Children’s Research Hospital used a series of cryo-EM structures to visualize dynamics pivotal to chromatin remodeling, a process implicated in cancer and developmental ...

The cell's genetic material, DNA, is packaged into tightly wound structures called nucleosomes. The DNA (red) is wound around two sets of core histone proteins (green) to form a kind of bead on a ...

One chromatin remodeling mechanism called "nucleosome sliding" allows a nucleosome ... information inside the nucleus of the eukaryotic cell. Chromatin remodelers help the cell access and ...

This study provides valuable findings on the role of site-specific DNA methylation changes during spermatogenesis and their contribution to paternal epigenetic inheritance. The study proposes that ...

A study by scientists at the Herbert Irving Comprehensive Cancer Center (HICCC) introduces a more cost-effective, scalable ...

The chip that is inserted into the 10X Genomics software, allowing researchers to analyze DNA and RNA simultaneously.

To date, potent, selective and cell-active NSD2 inhibitors have not been described. A platform was established for the discovery of selective NSD2 inhibitors from quantitative high-throughput ...

2 The team fused DAAO to either a nucleosome protein or a mitochondrial membrane protein to study the effects ... Additionally, DAAO-produced hydrogen peroxide at the mitochondria membrane did not ...

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