We previously introduced the concept of 'oncogene addiction' to explain how some cancers that contain multiple genetic, epigenetic, and chromosomal abnormalities are dependent on or 'addicted' to ...

What drives cancer cells to grow and divide uncontrollably turning into cancer? Studies of proto-oncogenes reveal some clues about how normal cellular processes mutate and go awry.

serving as a foundation for the now widely accepted phenomenon called oncogene addiction 11. But the euphoria of blast-crisis remissions was short lived. Despite continued imatinib treatment ...

In view of this complexity, how can we identify the specific oncogene or oncogenes that have a critical role in maintaining the malignant phenotype in these different cancer types, or within ...