Tumor suppressor genes act as “brakes” to stop cells before they can travel down the road to cancer. A loss of function mutation in these genes can be disastrous. Like all genes, tumor ...

How is a normal cell transformed into a cancerous cell? The proteins involved in cell division events no longer appropriately drive progression from one cell cycle stage to the next. Cells that ...

IGFBP2表达评估idh突变的胶质瘤患者生存 （IGFBP2 expression predicts IDH-mutant glioma patient survival） ...

There are two types of genes that are important in the development and growth of cancers: oncogenes and tumor-suppressor genes. Most often, an accumulation of mutations in both oncogenes and tumor ...

But mutations in oncogenes do not inevitably cause cancer. Normally, cells are able to “fight back” against oncogene activity through genes called tumor suppressors. When activated, tumor suppressor ...

Identification of genes inactivated by promoter CpG methylation is a powerful approach to discover novel tumor suppressor candidates. PCDH10suppresses gastric cancer cell growth through cell ...

View Full Profile. Learn about our Editorial Policies. Ten years later, it changed from an oncogene to a tumor suppressor gene. And that just changed the field completely. - Arnold Levine, Institute ...

Northwestern Medicine scientists have uncovered a key pathway controlling tumor growth in B-cell lymphomas, according to a ...

In most human tumor cells, the mutant protein accumulates to high levels because ... "The cited paper reviewed the p53 field and addressed the critical issue of whether the p53 gene acted only as a ...