When you’re awake, those neurons send out orexins. The orexins then bind to certain orexin receptors on other neurons. When that happens, the amount of activity of those neurons goes up.

reinforcing the role of orexin in sleep pathways. "We are working to quickly assess the totality of available data to inform the further development of TAK-994," commented Sarah Sheikh ...

In 1998, we purified a novel neuropeptide orexin and showed that this peptide plays pivotal roles in the regulation of appetite and sleep. In this ERATO project, we showed that the administration of ...

Idorsia has become the first drugmaker in the EU to claim approval for a drug for chronic insomnia in the dual orexin receptor antagonist class, ahead of rival drugs from Merck & Co and Eisai.