为探究砷（As）对鲤鱼脾脏的毒性机制以及锌（Zn）是否能通过 P38 MAPK/Nrf2/HO-1 通路缓解 As 诱导的氧化应激和炎症损伤，研究人员开展相关研究。结果发现 Zn 可减轻 As 诱导的脾脏损伤，这为 Zn 的解毒机制及在水产养殖中减轻重金属毒性提供了新见解。 砷（As ...

JNK/p38 MAPK的协同调控 磷酸化抗体检测发现WD同步激活JNK和p38 MAPK，双通路抑制剂联用比单抑制剂更显著降低凋亡率（p<0.01）。图4A展示通路蛋白表达变化，但被质疑与图3A存在图像重叠。 体内外实验验证治疗潜力 小鼠异种移植模型中，WD组肿瘤体积减少70% ...

One target for such inhibition, the p38 mitogen-activated protein kinase (MAPK) signaling cascade, has a role in inflammation by mediating the cellular response to stress, pathogens, and cytokines.

Mitogen-activated protein kinase (MAPK) and Wnt signaling pathways are ... In addition, phosphorylation of p38, ERK and JNK proteins was investigated. Immunofluorescence analysis of MITF was ...