Several pieces of evidence indicate that the tumour suppressor p27 (encoded by CDKN1B) has other functions beyond its role as a cell-cycle inhibitor. James Roberts, Arnaud Besson and colleagues ...

Failure to control the cell cycle adequately can lead to diverse life-threatening diseases such as cancer. Figure 2: Deregulation of p27 protein turnover contributes to tumorigenesis.

Further studies are required to verify whether this regulation of cell cycle progression occurs in ... Promotes Cell Proliferation via the SKP2-p27 Axis in Luminal Androgen Receptor Subtype ...

AKT regulates the cell cycle by phosphorylating FoxO1 and decreasing its transcription of CDK inhibitors p21 and p27. AKT, protein kinase B; CDK, cyclin dependent kinase; FoxO1, forkhead box O1 ...