One notable exception is the cyclin-dependent kinase inhibitor p27 Kip1. p27 is an inhibitor of the cell cycle, and thus a candidate tumor suppressor by birthright. But the homozygous loss or ...

Several pieces of evidence indicate that the tumour suppressor p27 (encoded by CDKN1B) has other functions beyond its role as a cell-cycle inhibitor. James Roberts, Arnaud Besson and colleagues ...

Failure to control the cell cycle adequately can lead to diverse life-threatening diseases such as cancer. Figure 2: Deregulation of p27 protein turnover contributes to tumorigenesis.

AKT regulates the cell cycle by phosphorylating FoxO1 and decreasing its transcription of CDK inhibitors p21 and p27. AKT, protein kinase B; CDK, cyclin dependent kinase; FoxO1, forkhead box O1 ...